Kewchang Lee, a psychiatrist who oversees mental health consultations at the San Francisco Veterans Affairs Medical Center, is not used to being studied.

But in recent weeks, Lee signed up to be part of a first-of-its-kind experiment that is playing out in 21 VA health centers around the country, including San Francisco and Palo Alto.

For the first time since he began practicing medicine in 1992, Lee is asking a small number of his patients to take a cheek swab for a genetic test analyzing their ability to metabolize commonly prescribed antidepressants. Lee uses the information to help decide which and how much of an antidepressant to prescribe.

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